Abstract Background Transfusion-dependent thalassaemia (TDT) is a hereditary blood disorder in which blood transfusion is the mainstay treatment to prolong survival and improve quality of life.Patients with this disease require blood transfusion at more than 100 ml/kg annually and iron-chelating therapy (ICT) to prevent iron overload (IOL) complica
Silence of a dependence receptor CSF1R in colorectal cancer cells activates tumor-associated macrophages
Background Colony-stimulating factor 1 receptor (CSF1R), a classic tyrosine kinase receptor, has been identified as a proto-oncogene in multiple cancers.The CSF1/CSF1R axis is essential for the survival and differentiation of M2-phenotype tumor-associated macrophages (M2 TAMs).However, we found here that the CSF1R expression was abnormally down-reg
Lopadostoma, Oligostoma, and some Rosellinia specimens from the herbarium of the Swiss Federal Institute of Technology (ZT): the value of early fieldwork and the importance of keeping fungal collections
Abstract Background Morphology, hosts, and collecting sites of fungi assessed from herbarium material Dog Mats of special interest deserve to be brought to the attention of mycologists.Results Specimens of Lopadostoma and Oligostoma deposited at ZT are briefly described and listed to expand the knowledge about their distribution.Three yet unmention